Computational Pathology @
The Netherlands Cancer Institute
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SELECTED Publications
Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial.
Nat Med. 2019 Jun;25(6):920-928.PMID: 31086347
Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer.
Breast Cancer Res. 2019 Dec 26;21(1):151.PMID: 31878981
A specific gene expression signature for visceral organ metastasis in breast cancer.
BMC Cancer. 2019 Apr 8;19(1):333.
Cancer-Associated Mutations in Endometriosis without Cancer.
N Engl J Med. 2017 May 11;376(19):1835-1848
Frequent NFIB-associated Gene Rearrangement in Adenoid Cystic Carcinoma of the Vulva.
Int J Gynecol Pathol. 2017 May;36(3):289-293.
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis.
Nature. 2010 Apr 15;464(7291):1071-6.
Using Somatic Mutations to Guide Treatment Decisions: Context Matters.
JAMA Oncol. 2015 Jun;1(3):275-6.PMID: 26181166
ESR1 gene amplification in breast cancer: a common phenomenon?
Nature Genetics volume 40, pages807–808(2008)
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Cancer Cell. 2007 Oct;12(4):395-402.